Hormonal and Metabolic Status of Male Rats with Metabolic Syndrome Model Induced by Interruption of Breastfeeding in the Early Postnatal Period

A short-term deprivation of rat pups from breastfeeding in the early postnatal period leads to MS at age 4-6 months. However, this neonatal model requires optimization and a detailed study into metabolic hormonal parameters adult animals. The aim work was these male rats deprived breast milk 19-21 days, which achieved by treating lactating females with bromocriptine. Adult showed an increased body weight adipose tissue, impaired glucose tolerance, insulin resistance, hyperleptinemia. These animals had reduced levels testosterone, free thyroxine, total triiodothyronine, increase thyroid-stimulating hormone. Thus, development endocrine dysregulations.